Semen analysis as a biomarker of male aging: biological mechanisms, clinical implications, and public health perspectives

The Live 2025 ESHRE Journal Club discussion focused on a study by on the association between impaired semen quality and less healthy male aging. The discussion focused on the topic of semen analyses and men’s health, including (A) the methodological robustness of large-scale semen analyses; (B) the biological mechanisms correlating semen quality and disease and the clinical use of semen analysis to guide a broader health assessment; and (C) whether semen quality should be adopted as a routine biomarker in public health and preventive frameworks.