Why the study?
The TiaoGanXiaoZhi formula has been shown clinically to alleviate metabolic-associated fatty liver disease progression, but its underlying mechanism remains unclear.
Does the TiaoGanXiaoZhi formula alleviate the progression of metabolic-associated fatty liver disease in a mouse model?
Population
42 mice fed normal or high-fat diet with 5% fructose water
Comparison
TGXZ vs placebo or distilled water across NFD and HFD groups
Design
Animal experimental study
Follow-up
16 weeks
Key result
In a mouse model of MAFLD, TGXZ treatment significantly reduced white adipose tissue weight (1.61 vs. 3.06 g, P<0.0010), liver weight, and improved lipid profiles and liver enzymes.
Authors
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Supports TGXZ in mouse MAFLD models; hypothesis-generating and should not change practice.
Does the TiaoGanXiaoZhi formula alleviate the progression of metabolic-associated fatty liver disease in a mouse model?
Absolute Event Rate: 1.61% vs 3.06%
p-value: p=<0.0010
In a mouse model of MAFLD, the traditional Chinese medicine TGXZ improved lipid metabolism, reduced hepatic inflammation, and alleviated disease progression.
Qi et al. (2025) studied Metabolic-associated fatty liver disease (MAFLD) (n=42). TiaoGanXiaoZhi formula (TGXZ) vs. Placebo / distilled water was evaluated on Weight of white adipose tissue (g) (p=<0.0010). In a mouse model of MAFLD, TGXZ treatment significantly reduced white adipose tissue weight (1.61 vs. 3.06 g, P<0.0010), liver weight, and improved lipid profiles and liver enzymes.