January 9, 2009Catheterization and Cardiovascular Interventions
Antiplatelet therapy after endovascular intervention: Does combination therapy really work and what is the optimum duration of therapy?
Why the study?
Does combination antiplatelet therapy reduce cardiovascular events in patients with peripheral arterial disease undergoing endovascular interventions?
Population
Patients with peripheral arterial disease undergoing endovascular interventions
Comparison
Combination antiplatelet therapy vs Monotherapy with either aspirin or clopidogrel
Design
Review
Authors
Discussion
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Member takes
Implication
May support event reduction with combination antiplatelet therapy in PAD interventions; leaves open optimal duration and need for prospective trials.
Structured PICO
Does combination antiplatelet therapy reduce cardiovascular events in patients with peripheral arterial disease undergoing endovascular interventions?
P
Population
Patients with peripheral arterial disease undergoing endovascular interventions
I
Intervention
Combination antiplatelet therapy (aspirin with ticlopidine or clopidogrel)
C
Comparator
Monotherapy with either aspirin or clopidogrel
O
Outcome
Cardiovascular events (stroke, myocardial infarction, and cardiovascular death) and graft occlusionhard clinical
Combination antiplatelet therapy may reduce cardiovascular events after peripheral endovascular interventions, but further data are needed to define optimal duration.
Cite This Study
Richard V. Milani (2009) studied this question.