Distinct protein kinase C isoforms drive cell cycle re-entry in different populations of neonatal rat ventricular cardiomyocytes, highlighting potential pathways for cardiac regeneration.
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Should not yet change clinical practice for regeneration; hypothesis-generating for PKC isoform selectivity in neonatal cardiomyocytes.
The appearance of nestin(+)-neonatal rat ventricular cardiomyocytes that re-entered the cell cycle following phorbol ester stimulation in the presence of p38α/β MAPK inhibitor SB203580 was associated with the inhibition of Runx1 and CDKN2a mRNA upregulation. PKC-α selectively induced the cell cycle re-entry of nestin(+)-neonatal rat ventricular cardiomyocytes. Pharmacological inhibition of PKC-α with concomitant p38α/β MAPK suppression unmasked the cell cycle re-entry of a second population of neonatal rat ventricular cardiomyocytes in the absence of nestin expression.
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Kebbe et al. (2023) studied this question.
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