Why the study?
Does brief rapid pacing depress contractile function in cat ventricular myocytes?
Population
Cat ventricular myocytes
Comparison
Brief rapid pacing vs Control/baseline conditions
Design
Preclinical
Authors
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May link paroxysmal tachyarrhythmias to myocyte dysfunction; leaves open in vivo relevance and PKC-targeted interventions.
Does brief rapid pacing depress contractile function in cat ventricular myocytes?
Brief rapid pacing depresses contractility in ventricular myocytes via Ca2+/PKC-dependent signaling, providing insight into contractile dysfunction following paroxysmal tachyarrhythmias.
Wang et al. (2001) studied this question.
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