also seems to improve pulmonary function even when oral corticosteroids were reduced or discontinued. Given the retrospective nature of this study and the small number of cases analysed, the results must be interpreted with caution. Although all patients met the criteria of APBA proposed by Rosenberg, 7 the differentiation between this entity and Aspergillus-induced asthma is problematic, so we decided to blanket them under the term ' Aspergillus-associated airway disease'. While the pathogenesis of ABPA remains not fully understood, IgE has been advocated as a key pathogenic mechanism of the disease. Since the total serum IgE level is a marker of immunological activity in ABPA, the attenuation of the hyper-IgE response seems to be a reasonable target. Further studies are warranted to clarify the utility of omalizumab in AAAD, especially in ABPA.
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Lebecque et al. (2010) studied this question.