Fibroplastic Endocarditis With Eosinophilia (Löffler's Endocarditis Parietalis Fibroplastica): Case Report and Review of Literature

Case Reports1 March 1955FIBROPLASTIC ENDOCARDITIS WITH EOSINOPHILIA (LÖFFLER'S ENDOCARDITIS PARIETALIS FIBROPLASTICA): CASE REPORT AND REVIEW OF LITERATUREF. G. HOFFMAN, DAVID ROSENBAUM, M.D., P. D. GENOVESE, M.D.F. G. HOFFMAN, DAVID ROSENBAUM, M.D., P. D. GENOVESE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-668 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1936 Löffler published a report of two patients with a hitherto unclassified type of endocarditis.1, 9 This entity, subsequently referred to as fibroplastic endocarditis or Löffler's endocarditis parietalis fibroplastica, is characterized by an afebrile course, progressive, refractory congestive failure and a striking eosinophilia. The cases reported by Löffler, in addition, exhibited signs of mitral valvulitis, though these were inadequate to account for the clinical picture.Until 1948 only six cases had been reported, all in the Swiss and German literature. Lennox2called attention to this entity and published a report of a possible early stage of Löffler's endocarditis. The...Bibliography1. Löffler W: Endocarditis parietalis fibroplastica mit Blut eosinophile, Schweiz. med. Wchnschr. 66: 817, 1936. Google Scholar2. Lennox B: Acute parietal endocarditis in a case of status asthmaticus: a possible early stage of Löffler's endocarditis parietalis fibroplastica with eosinophilia, J. Path, and Bact. 60: 621, 1948. CrossrefGoogle Scholar3. Gould SE: Pathology of the heart, 1953, Charles Thomas, Springfield, Ill. Google Scholar4. SmithFurth JJJ: Fibrosis of myocardium with mural thrombosis: notes on its relation to isolated (Fiedler's) myocarditis and to beri-beri, Arch. Int. Med. 71: 602, 1943. CrossrefGoogle Scholar5. Case Records, Mass. General Hospital, Case 39441, New England J. Med. 249: 734 (Oct.) 1953. CrossrefMedlineGoogle Scholar6. BenchimalSchlesinger ABP: Beri-beri heart disease, Am. Heart J. 46: 245 (Aug.) 1953. CrossrefMedlineGoogle Scholar7. Harkavy J: Vascular allergy: pathogenesis of bronchial asthma with recurrent pulmonary infiltration and eosinophilic polyserositis, Arch. Int. Med. 47: 209, 1941. Google Scholar8. Golper MN: Endocardial fibro-elastosis, Radiology 61: 865, 1953. CrossrefMedlineGoogle Scholar9. Friedberg CK: Diseases of the heart, 1950, W. B. Saunders Co., Philadelphia. Google Scholar10. AdamsKatz FNB: Endocardial fibro-elastosis, J. Pediat. 41: 141, 1952. CrossrefMedlineGoogle Scholar11. CollierRosahn FCPD: Endocardial fibro-elastosis, Pediatrics 7: 175, 1951. MedlineGoogle Scholar12. CosgroveKaump GEDH: Endocardial sclerosis in infants, Am. J. Clin. Path. 16: 322, 1946. CrossrefMedlineGoogle Scholar13. PriorWyatt JTTC: Endocardial fibro-elastosis: a study of eight cases, Am. J. Path. 26: 969 (Nov.) 1950. MedlineGoogle Scholar14. WeinbergHimmelfarb TAJ: Endocardial fibro-elastosis (so-called fetal endocarditis), Bull. Johns Hopkins Hosp. 72: 299, 1943. Google Scholar15. Reinhart W: Die isolierte diffuse interstitielle eosinophile Myokarditis, Cardiologia 11: 219, 1947. CrossrefGoogle Scholar16. Gray I: Endocardial fibrosis, Brit. Heart J. 13: 387 (July) 1951. CrossrefMedlineGoogle Scholar17. Davies JN: Endocardial fibrosis in Africans, East African M. J. 25: 10, 1948. Google Scholar18. Löffler W: Pathogenetic significance of the so-called endocarditis parietalis fibroplastica, Bull. schweiz. Akad. d. med. Wissensch. 2: 287, 1946-7. Google Scholar19. Roulet F: Beitrag zur Kenntnis der Endocarditis parietalis fibroplastica mit Bluteosinophile (Löffler), Schweiz. med. Wchnschr. 74: 427, 1944. Google Scholar20. Mumme C: Zur Klinik und Pathologie der Endokarditis und Aortitis fibroplastica sowie Thromboendarteritis obliterans mit hochgradiger Eosinophilie im Blut, Knochenmark und in den Organen, Ztschr. f. klin. Med. 138: 22, 1940. Google Scholar21. Medical Grand Rounds Case 187: Familial idiopathic hypertrophy of the heart: ACTH treatment, Am. Pract. and Digest Treat. 2: 890, 1951. MedlineGoogle Scholar22. Deus P: Ueber Sepsis lenta, Cor.-Bl. f. Schweiz. Aerzte 46: 1473 (Oct.) 1916. Google Scholar23. Egger P: Endocarditis obliterans. Ihre Beziehungen zur Endocarditis parietalis fibroplastica mit Bluteosinophile und zum Morbis Buerger, Schweiz. Ztschr. f. Path. Bakt. 7: 237, 1944. Google Scholar24. Prior JT: Congenital anomalies of the mitral valve, Am. Heart J. 46: 649 (Nov.) 1953. CrossrefMedlineGoogle Scholar25. Buchler H: Eosinophile, Mikrobielle Endoallergie. Ein einheitlicher klinisch-pathogenetischer Formenlsresis, Ztschr. f. klin. Med. 140: 56-73, 1941. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 26, 1954.From the Veterans Administration Hospital, Indianapolis, Indiana.Sponsored by the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are a result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEosinophilia attention, diagnosis, treatment, and awareness in physicians: a cross-sectional surveyHypereosinophilic syndrome: approach to treatment in the era of precision medicineLoeffler's endocarditis presenting as mitral and tricuspid stenosisUnique Eosinophil Granules in a Case of T-Cell LymphomaEosinophilic ascitesUnusual hemodynamics in löffler's endomyocarditisParietal Fibroplastic Endocarditis (Loeffler's Disease): Radiological and Surgical Aspects in Connection with a Case ReportConduction disturbances and pacemaker failure in Löffler's endomyocarditisHypereosinophilic syndromeEosinophilie Leukemia Report of Five Cases and Review of LiteratureDAN S. BENVENISTI, M.D., F.A.C.P., JOHN E. ULTMANN, M.D., F.A.C.P.IN VIVO DIAGNOSIS OF LÖFFLER'S ENDOCARDITIS PARIETALIS FIBROPLASTICAThe Hypereosinophilic SyndromesWILLIAM R. HARDY, M.D., ROBERT E. ANDERSON, M.D.Endocarditis parietalis fibroplastica (Löffler's disease)Fibroplastic parietal endocarditis with eosinophiliaZur Diagnostik, Differentialdiagnostik und Haemodynamik der Pericarditis constrictiva, der sog. idiopathischen Myokardhypertrophie und der EndokardfibrosenDie Erkrankungen des Wandendokards unter besonderer Berücksichtigung ihrer pathologischen AnatomieDie konstriktive Perikarditis und die Ergebnisse ihrer operativen BehandlungINFILTRATIVE EOSINOPHILIA OF THE STOMACH AND SMALL BOWEL WITH ASSOCIATED MACROCYTIC ANÆMIA: REPORT OF A CASEAdult Endocardial Fibroelastosis Associated with Dextrocardia and Situs InversusDIFFUSE ENDOMYOCARDIAL SCLEROSIS: REPORT OF A CASEErkrankungen des EndokardZur morphologischen Pathologie und Klinik der Endocarditis parietalis fibroplastica mit Bluteosinophilie (L�ffler)Die Endokard-FibroelastoseMyocarditis with endocardial elastomyofibrosis (EEMF)Zur Fibroelastosis endocardica unter besonderer Berücksichtigung der Diagnose intra vitamEXPERIMENTAL PRODUCTION OF ENDOMYOCARDIAL FIBROSISEndocarditis parietalis fibroplastica mit Bluteosinophilie (L�ffler) bei einem siebenj�hrigen Kind (Erstbeschreibung im Kindesalter)Idiopathic Myocardial Failure in the Last Trimester of Pregnancy and the PuerperiumLöffler's endocarditis parietalis fibroplastica with eosinophiliaPERIARTERITIS NODOSAEndocardial Fibrosis Simulating Constrictive Pericarditis 1 March 1955Volume 42, Issue 3Page: 668-680KeywordsEndocarditisEosinophilia ePublished: 1 December 2008 Issue Published: 1 March 1955 PDF downloadLoading ...