After a single oral dose of 0.5 or 0.75 g of aureomycin given to fasting normal subjects antibiotic activity was recovered in the urine for more than 33 to 55 hours. The antibiotic was excreted in high concentrations between 2 and 16 hours and the largest rate of excretion occurred between 2 and 8 hours. The findings suggest that the optimum intervals between oral doses of aureomycin should be about 8 hours.
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Collins et al. (1948) studied this question.