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Megakaryocytes may mimic tumor cells in blood smears; leaves open reliable detection of circulating cancer cells in observational reports.
BECAUSE of the frequency of lung and liver metastasis in the spread of certain malignant tumors it has long been accepted that malignant tumors may invade blood vessels, particularly veins, and create showers of tumor emboli, which may be disseminated in this fashion to areas remote from the primary tumor. Repeated searches have been made for malignant cells in the blood, both in the peripheral veins and in veins draining the site of the primary tumors.Among the early successful reports of the finding of malignant cells in venous blood have been those of Ward1 and Pool and Dunlop.2 More . . .
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Raker et al. (1960) studied this question.
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