The most important methods for the preparation of polyfunctional Zn and Mg reagents are highlighted. New perspectives for increasing the synthetic potential of these reagents including the use of Lewis acid catalysis, in situ trapping reactions, continuous flow conditions, and solid, air-stable zinc organometallics are described. 1 Introduction 2 Preparation Methods 3 Air-Stable Solid Organozinc Reagents 4 Lewis Acid Catalyst Compatibility with Polyfunctional Zinc and Magnesium Organometallics 5 Metalations in Flow Mode 6 Conclusion
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Knochel et al. (2016) studied this question.