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Convenient metalation procedures: Directed manganation using tmp2Mn⋅2 MgCl2⋅4 LiCl leads to the corresponding diorganomanganese reagents in high yields at 0–25 °C. Remarkably, a number of functionalities as well as sensitive heterocycles are tolerated in this metalation procedure (see scheme). The organomanganese species react with a great variety of electrophiles and undergo efficient oxidative amination reactions.
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Wunderlich et al. (2009) studied this question.
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