Why the study?
Adipose tissue undergoing cachectic dystrophy can histologically mimic signet ring cell morphology, representing a diagnostic pitfall.
Lipodystrophied adipocytes in cachexic patients can histologically mimic signet ring cell adenocarcinoma, representing a significant diagnostic pitfall.
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Pathologists should recognize lipodystrophied adipocytes as a signet-ring mimic in cachexia to avoid misdiagnosis; single case report leaves broader applicability open.
Cachexia is a complex syndrome and a comorbid condition commonly associated with a variety of chronic diseases like cancer, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease and AIDS cancer. It results from metabolic dysregulation and is characterized by profound loss of adipose tissue and skeletal muscles. Approximately 20% of deaths in cancer patients are due to cachexia. Adipose tissue after undergoing cachectic dystrophy may mimics signet ring cell morphology histologically. Such lipodystrophied adipocytes mimicking signet ring cells are a diagnostic pitfall. We present a case of 54 years old male presenting with complains of pain upper abdomen for 1.5 years along with dysphagia and vomiting for last 4-5 months, diagnosed as moderately differentiated adenocarcinoma, biopsy pyloric stricture with metastatic tumor deposits in omental lymph node and lipodystrophy of adipocytes in the perinodal tissue.
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Dr Abhilash Singh (2021) studied this question.
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