Occurrence of Symptoms of Sickle Cell Disease in the Absence of Persistent Anemia

Article1 April 1951OCCURRENCE OF SYMPTOMS OF SICKLE CELL DISEASE IN THE ABSENCE OF PERSISTENT ANEMIATHOMAS W. GREEN, M.D., C. LOCKARD CONLEY, M.D.THOMAS W. GREEN, M.D.Search for more papers by this author, C. LOCKARD CONLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-4-849 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of bone and joint pain, abdominal pain, jaundice and other symptoms in patients with sicklemia has generally been associated with the presence of persistent anemia. According to general belief, individuals who are found to have the sickle cell trait in the absence of anemia do not subsequently develop manifestations of the disease. On the other hand, persons with sickle cell anemia are not believed to undergo remissions so complete that the blood picture becomes normal.1In 1929 Levy2reported three cases of supposed sickle cell disease with periods of symptoms and anemia followed by intervals in which normal...Bibliography1. Wintrobe MM: Clinical hematology, 1946, Lea and Febiger, Philadelphia, pp. 501-518. Google Scholar2. Levy J: Sicklemia, Ann. Int. Med. 3: 47-54, 1929. LinkGoogle Scholar3. Bauer J: Sickle cell disease; pathogenic, clinical and therapeutic considerations, Arch. Surg. 41: 1344-1362, 1940. CrossrefGoogle Scholar4. BauerFisher JLJ: Sickle cell disease with special regard to its non-anemic variety, Arch. Surg. 47: 553-563, 1943. CrossrefGoogle Scholar5. CanbyCarpenterEllmore CBGLF: Drepanocytosis (sicklemia) and an apparently acute surgical condition of the abdomen, Arch. Surg. 48: 123-125, 1944. CrossrefGoogle Scholar6. AbelBrown MSCR: Sickle cell disease with severe hematuria simulating renal neoplasm, J. A. M. A. 136: 624-625, 1948. CrossrefMedlineGoogle Scholar7. ThompsonWagnerMacLeod RKJACM: Sickle cell disease; report of case with cerebral manifestations in the absence of anemia, Ann. Int. Med. 29: 921-928, 1948. LinkGoogle Scholar8. Campbell EH: Acute abdominal pain in sickle cell anemia, Arch. Surg. 31: 607-621, 1935. CrossrefGoogle Scholar9. SilvestroniBianco EI: Una nuova etita nosologica: "la malattia microdrepanocitica," Haematologica 29: 455-488, 1946. Google Scholar10. DalandCastle GAWB: A simple and rapid method for demonstrating sickling of the red blood cells: the use of reducing agents, J. Lab. and Clin. Med. 33: 1082-1088, 1948. MedlineGoogle Scholar11. ThomasStetson LTCA: Sulfhydryl compounds and the sickling phenomenon, Bull. Johns Hopkins Hosp. 83: 176-180, 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication April 7, 1949.From the Division of Clinical Microscopy, Department of Medicine, The Johns Hopkins University and Hospital, Baltimore. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnterior and Posterior Hypopituitarism Associated with Sickle Cell TraitROBERT A. PASTURE, JAMES W. ANDERSON, ROBERT H. HERMANNiere bei Tumoren, Blutkrankheiten und ParaproteinämienSickle Cell Trait and Superior Longitudinal Sinus ThrombosisERIC A. SCHENK, M.D.Avascular Necrosis of the Femoral Head Associated with Sickle Cell Trait (AS Hemoglobin)RALPH G. RATCLIFF, M.D., MELVYN D. WOLF, M.D.Fatal Intravascular Sickling in a Patient with Sickle-Cell TraitConsiderazioni su un caso di due Gemelle Monozigotiche affette da Anemia DrepanociticaSickle-cell thalassemia (microdrepanocytic disease) in pregnancyIncidence of blood dyscrasias in the non-Europeans as seen in Southern AfricaGross hematuria in sickle cell trait and sickle cell hemoglobin-C diseaseThe Human Hemoglobins in Health and DiseaseSICKLEMIA*†NORMAN ENDE, M.D., PHILIP PIZZOLATO, M.D., JOSEPH ZISKIND, M.D., F.A.C.P.THE THERAPEUTIC RESPONSE OF TUBERCULOUS NEGROES WITH THE SICKLE CELL TRAIT*WILLIAM WEISS, M.D.Sickle Cell AnemiaConstitutional Pathology of Erythropoiesis 1 April 1951Volume 34, Issue 4Page: 849-855KeywordsAbdominal painAnemiaArthralgiaBlood cellsBoneHospital medicineMicroscopySickle cell disease ePublished: 1 December 2008 Issue Published: 1 April 1951 Copyright & PermissionsCopyright, 1951, by The American College of PhysiciansPDF downloadLoading ...