The Pathology of Sickle Cell Disease

Article1 September 1945THE PATHOLOGY OF SICKLE CELL DISEASEROBERT C. MURPHY JR., M.D., SHEPARD SHAPIRO, M.D.ROBERT C. MURPHY JR., M.D., SHEPARD SHAPIRO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-3-376 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe incidence of the sickle cell trait among North American Negroes has been estimated from various surveys to be 7 per cent,237.2 per cent,109.1 per cent6aand even as high as 13 per cent1aof the Negro population. Clinical sickle cell disease appears in an undetermined fraction of cases in which the trait is present, estimates of this ratio varying from 1:7 to 1:40.23As far as can be determined the trait is transmitted as a true Mendelian dominant,12, 15, 23, 33independent of the inheritance of blood type.23This apparent fact has been used as an argument...Bibliography1. BAUER J: Sickle cell disease, Arch. 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H. SULLIVAN JR.Pregnancy with sickle cell anemiaSyphilis, Tuberculosis, and Sickle-Cell anaemia: REPORT OF A CASE 1 September 1945Volume 23, Issue 3 Page: 376-397 Keywords Biopsy Blood cells Sickle cell disease ePublished: 1 December 2008 Issue Published: 1 September 1945 PDF downloadLoading ...