February 2, 2010Circulation

Noninvasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model

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Why the study?

Does extracardiac histotripsy successfully create an atrial septal defect in an open-chest canine model?

Structured PICO

Does extracardiac histotripsy successfully create an atrial septal defect in an open-chest canine model?

Population

10 canines in an open-chest model

Intervention

Extracardiac application of histotripsy (ultrasound pulses of 6-microsecond duration at a peak negative pressure of 15 MPa and a pulse repetition frequency of 3.3 kHz generated by a 1-MHz focused transducer) guided by real-time ultrasound imaging

Outcome

Creation of an atrial septal defect and visualization of shunting across the atrial septumsurrogate

Extracardiac histotripsy successfully created atrial septal defects with minimal surrounding tissue damage in an open-chest canine model, showing promise as a noninvasive procedure for neonates with hypoplastic left heart syndrome.

Limitations

Open-chest model used; further studies in an intact animal model are needed

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

ASD creation feasible in most canines with minimal damage; leaves open translation to neonates with HLHS.

Cite This Study

Xu et al. (2010) studied this question.

synapsesocial.com/papers/6a8c7edc4041bb0c0f4e07f4 https://doi.org/10.1161/circulationaha.109.889071

View Full Paper

Ask AI

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Noninvasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Noninvasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider