Preclinical study reveals diallyl trisulfide suppresses tobacco-carcinogen-induced lung cancer by modulating gut microbiota and inflammatory pathways, suggesting its chemopreventive potential.
, which has inhibitory effects on tumor growth. Mechanistically, DATS could activate the PPARγ pathway, leading to the negative regulation of the NF-κB signaling pathway and subsequent suppression of NF-κB-mediated inflammatory factors. Collectively, these findings provide support for DATS as a potential novel chemopreventive agent for tobacco carcinogen-induced lung cancer.
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Qu et al. (2023) studied this question.
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