The Lewis acid induced isomerisation of 2,3-epoxy amines into the corresponding 2-trimethylsiloxymethylaziridinium ions is described; such intermediates have been characterised by 1H NMR spectroscopy, and react with nitrogen nucleophiles regiospecifically to form 1-substituted 2, 3-diamino alcohols in good to excellent yields and with full stereochemical control.
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Liu et al. (1994) studied this question.
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