Immunogenic cell death (ICD) facilitates danger signalling-driven trafficking of damage-associated molecular patterns (DAMPs) like extracellular ATP (eATP). 1 , 2 The binding of eATP to P 2 X 7 receptor triggers immunogenic signalling, 3 which (along with other factors) converts the dying cancer cells into an effective anticancer vaccine. 3
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Garg et al. (2016) studied this question.
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