February 23, 2008Cardiovascular ResearchOpen Access

Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel

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Population

Cardiomyocytes isolated from heart ventricles of newborn rats

Design

Preclinical

Authors

Discussion

May modulate adrenergic LTCC regulation in animal models; hypothesis-generating for ENH1-PKD1 targeting in human cardiovascular disease.

Population

Cardiomyocytes isolated from heart ventricles of newborn rats

Intervention

Small interfering RNA (siRNA) against ENH1 and a dominant negative mutant of PKD1 delivered via adenovirus

Outcome

Protein interactions between ENH1, PKD1, and alpha1C, and L-type calcium currentssurrogate

ENH1 acts as a scaffold for PKD1 to alpha1C, forming a signaling complex that regulates cardiac L-type voltage-gated calcium channel activity.

Maturana et al. (2008) studied this question.

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