Why the study?
While adipocytes have been presumed to be the major source of hormonal FABP4, this question had not been addressed definitively in vivo.
Population
Mice with Fabp4 deletion in adipocytes, endothelial cells, myeloid cells, or the whole body, and WT controls
Comparison
Adipo-KO vs Endo-KO vs Myeloid-KO vs Total-KO vs WT controls
Design
Preclinical animal study
Authors
Loading...
Challenges adipocyte-centric FABP4 paradigm in mice; leaves open endothelial contributions to human metabolic disease.
The endothelium, rather than adipocytes, is the major source of baseline hormonal FABP4 and is required for the insulin response to lipolysis.
Inouye et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: