N,N′‐Alkylidenebisamides 1, totally unsuitable as amidoalkylating agents toward phosphorous acid, react with its “activated” form prepared “in situ” from phosphorus(III) chloride and acetic acid to give the desired 1‐aminoalkylphosphonic acids 2 in high yields.
No takes yet. Share an insight, caveat, or question.
Soroka et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: