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An inhibitor derived from popcorn prolonged the partial thromboplastin time of normal human plasma. The effect of this agent was localized to its inhibition of activated Hageman factor (factor XII), as demonstrated in amidolytic assays employing ellagic acid-activated Hageman factor and the carboxy-terminal fragment of Hageman factor (HFf.
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Ratnoff et al. (1981) studied this question.