Why the study?
Do heparins prevent or treat obstetrical syndromes in pregnant women?
Do heparins prevent or treat obstetrical syndromes in pregnant women?
Heparins are established for preventing gestational complications in antiphospholipid syndrome, but their role in other obstetrical syndromes remains debated.
Supports heparin for APS gestational complications; leaves open its role in other obstetrical syndromes.
Accumulating evidence supports the concept of increased thrombin generation, placental vascular lesions, and inflammation as crucial points in the development of the great obstetrical syndromes [preeclampsia, intrauterine growth restriction (IUGR), preterm labor (PTL), preterm prelabor rupture of membranes (PROM), fetal demise and recurrent abortions]. In light of this, the role of heparins for primary or secondary prevention of these syndromes is becoming more and more apparent, mainly due to the antithrombotic and anti-inflammatory effects of heparins. There is agreement regarding the use of heparin in the prevention of gestational complications in patients with antiphospholipid syndrome, while its use for other obstetrical complications is under debate. In the present review we will describe the physiologic role of heparins on coagulation and inflammation and we will discuss current evidence regarding the use of heparins for the prevention/treatment of obstetrical syndromes.
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Mastrolia et al. (2015) studied this question.
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