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Tuberactinomycin biosynthesis: Viomycin and capreomycin are structurally related antituberculosis drugs. Analysis of the nonribosomal peptide synthetases that assemble these molecules determined that peptide assembly occurs by distinct mechanisms. These unexpected differences provide insights into how modifications to homologous nonribosomal peptide synthetases can result in structure diversification.
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Felnagle et al. (2011) studied this question.
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