Previous work has established that part of the penicillin molecule (I), consisting of the side-chain nitrogen atom, N(8), the ,B-lactam carbon atoms, C(H7) , and the sulphur atom, is specifically derived from L-cysteine (Arnstein & Grant, 1954 b), whereas the carbon chain of the penicillamine moiety is derived from valine (Stevens, Vohra & DeLong, 1954; Arnstein & Grant, 1954a). It is not yet certain, however, whether L-or D-valine is specifically used for penicillin biosynthesis (Arnstein & Clubb, 1957).
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Arnstein et al. (1957) studied this question.
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