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August 1, 1991Neuroreport

Evidence that matrix recognition contributes to stabilization but not induction of LTP

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Why the study?

Do Arg-Gly-Asp (RGD) peptides affect the induction and stabilization of long-term potentiation in slices of hippocampus?

Population

Slices of hippocampus

Comparison

Arg-Gly-Asp (RGD) peptides vs Various non-RGD control peptides

Design

Preclinical

Follow-up

40 min

Authors

PXPeng XiaoBBBen A. BahrUSUrsula Stäubli

Discussion

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Overview

RGD peptides disrupt LTP stabilization in hippocampal slices; leaves open integrin-matrix roles in human synaptic plasticity or disease.

Structured PICO

Do Arg-Gly-Asp (RGD) peptides affect the induction and stabilization of long-term potentiation in slices of hippocampus?

P
Population
Slices of hippocampus
I
Intervention
Arg-Gly-Asp (RGD) peptides
C
Comparator
Various non-RGD control peptides
O
Outcome
Amount of long-term potentiation (LTP) expressed in the CA1 fieldsurrogate

This preclinical study suggests that stabilization of long-term potentiation requires adhesive interactions via specific matrix recognition sites, whereas induction and expression do not.

Cite This Study

Xiao et al. (1991) studied this question.

synapsesocial.com/papers/6a8ceb4a4847f413e42f0758https://doi.org/10.1097/00001756-199108000-00013
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