Population
Cerebral microvascular endothelial cells (CMVEC) cocultured with astrocytes (AS) (n=8 for thymidine assay)
Comparison
Cytochrome P-450 epoxygenase blockade by… vs Control (no blockade)
Design
Preclinical
Follow-up
up to 5 days
Authors
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Supports astrocyte-EET axis in cerebral angiogenesis in vitro; leaves open in vivo validation and therapeutic relevance.
Astrocytes promote cerebral angiogenesis in vitro through the release of epoxyeicosatrienoic acids.
Munzenmaier et al. (2000) studied this question.
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