A new kid in town: 3D Raman intensity images of a HT29 colon cancer cell incubated with an aqueous solution of the CO-releasing metal–carbonyl complex 1 show that the compound penetrates the cellular membrane and is localized mainly in the nuclear membrane and the nucleolus. The CO vibration of 1 serves as an intrinsic spectroscopic label.
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Meister et al. (2010) studied this question.
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