Structural Investigation of Cisplatin–Protein Interactions: Selective Platination of His19 in a Cuprozinc Superoxide Dismutase

Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper–zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green).