Synthesis, characterization and antineoplastic activity of 5-chloro-2,3-dihydroxypyridine transition metal complexes

Synthetic procedures are described that allow access to cis-[Mo2O5(cdhp)2]2−, cis-[W2O5(Hcdhp)2], trans-[OsO2(cdhp)2]2−, trans-[UO2(Hcdhp)2], [ReO(PPh3)(Hcdhp)2]X (X = Cl, I), [ReO2(cdhp)2]−, [M(PPh3)2(cdhp)], [M(bpy)(cdhp)] (M(II) = Pd, Pt), [Ru(YPh3)2(Hcdhp)2] (Y = P, As), [Rh(Hcdhp)2Cl(H2O)], [Rh(PPh3)2(Hcdhp)2]ClO4 and [Ir(bpy)(cdhp)Cl2], where Hcdhp, cdhp are the deprotonated monoanion of 5-chloro-3-hydroxypyrid-2-one and dianion of 5-chloro-2,3-dihydroxypyridine, respectively. These complexes were characterized by their Raman, IR, 1H NMR, electronic and mass spectra, conductivity, magnetic and thermal measurements. H2cdhp, cis-K2[Mo2O5(cdhp)2], [Pd(bpy)(cdhp)] display a significant antineoplastic activity against Ehrlich ascites tumor cells (EAC).