Regulatory Strategies in the Complexation and Release of a Noncovalent Guest Trimer by a Self‐Assembled Molecular Cage

Primitive similarities with regulatory strategies of natural systems have been mimicked by a synthetic self-assembled receptor. The complexation of a hydrogen-bonded trimer inside a hydrogen-bonded molecular cage triggers similar large conformational changes to the ones occurring in enzymes upon complexation of a specific substrate. Controlled release is also achieved (see scheme).