What is the clinical evidence from this study?

Study design: Cohort. Population: Metabolic dysfunction associated steatotic liver disease (MASLD) (n=3970). Intervention: Neutrophil percentage-to-albumin ratio (NPAR) vs. NPAR below the inflection point. Primary outcome: All-cause mortality (HR 1.37, 95% CI 1.01-1.86, p=<0.05).

What does this research mean for the field?

In patients with metabolic dysfunction-associated steatotic liver disease (MASLD), elevated neutrophil percentage-to-albumin ratio above the nonlinear inflection point is associated with higher all-cause and cardiovascular disease mortality. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 5, 2024Scientific ReportsOpen Access

Predictive role of neutrophil percentage-to-albumin ratio, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with MASLD

Q: What are the key findings of this study?

In patients with MASLD, NPAR above the inflection point was associated with higher all-cause mortality (HR 1.37; 95% CI 1.01-1.86) and CVD mortality (HR 2.03; 95% CI 1.24-3.32).

Q: What does this research mean for the field?

In patients with metabolic dysfunction-associated steatotic liver disease (MASLD), elevated neutrophil percentage-to-albumin ratio above the nonlinear inflection point is associated with higher all-cause and cardiovascular disease mortality. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Elevated NPAR linked to ~37% higher all-cause mortality in patients with MASLD.

HR 1.37
95% CI 1.01-1.86
P<0.05
n=3,970

Why the study?

Do elevated levels of NPAR, NLR, and SII predict all-cause and CVD mortality in patients with MASLD?

Study Design

Type

Cohort (n=3,970)

Structured PICO

Do elevated levels of NPAR, NLR, and SII predict all-cause and CVD mortality in patients with MASLD?

Population

3,970 participants with metabolic dysfunction associated steatotic liver disease (MASLD) from the NHANES dataset.

Exposure

Neutrophil percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII)

Comparator

Lower levels of NPAR, NLR, and SII (e.g., below nonlinear inflection points)

Outcome

All-cause mortality and cardiovascular disease (CVD) mortalityhard clinical

Main Result

Hazard Ratio: 1.37 (95% CI 1.01–1.86)

p-value: p=<0.05

Discussion

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Implication

Elevated NPAR and NLR are significant predictors of all-cause and cardiovascular mortality in patients with metabolic dysfunction associated steatotic liver disease.

Cite This Study

Dong et al. (2024) conducted a cohort in Metabolic dysfunction associated steatotic liver disease (MASLD) (n=3,970). Neutrophil percentage-to-albumin ratio (NPAR) vs. NPAR below the inflection point was evaluated on All-cause mortality (HR 1.37, 95% CI 1.01-1.86, p=<0.05). In patients with MASLD, NPAR above the inflection point was associated with higher all-cause mortality (HR 1.37; 95% CI 1.01-1.86) and CVD mortality (HR 2.03; 95% CI 1.24-3.32).

synapsesocial.com/papers/6a8cf3825ab75fc7bb2795fb https://doi.org/10.1038/s41598-024-80801-8

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Implication

Elevated NPAR and NLR are significant predictors of all-cause and cardiovascular mortality in patients with metabolic dysfunction associated steatotic liver disease.

Predictive role of neutrophil percentage-to-albumin ratio, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with MASLD

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Predictive role of neutrophil percentage-to-albumin ratio, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with MASLD

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider