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September 1, 2015Physiological ReportsOpen Access

Cardiac melanocytes influence atrial reactive oxygen species involved with electrical and structural remodeling in mice

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Population

Dct-null and Dct-heterozygous mice, and isolated cardiac melanocyte-like cells and atrial myocytes

Comparison

Exposure to hydrogen peroxide or treatment with… vs Dct-het mice/cells, or untreated controls

Design

Preclinical

Authors

HHHayoung HwangFLFang LiuNPNataliya Petrenko

Discussion

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Overview

Dct loss heightens atrial oxidative sensitivity and fibrosis in mice; leaves open any role in human atrial arrhythmogenesis.

Structured PICO

P
Population
Dct-null and Dct-heterozygous (Dct-het) mice, and isolated cardiac melanocyte-like cells (CMLCs) and atrial myocytes
I
Intervention
Exposure to hydrogen peroxide (in vitro) or treatment with ROS scavenger Tempol (in vivo)
C
Comparator
Dct-het mice/cells, or untreated controls
O
Outcome
Atrial oxidative stress, structural remodeling (fibrosis), and electrophysiological response (action potential duration and afterdepolarizations)surrogate

Dopachrome tautomerase (Dct) within cardiac melanocyte-like cells plays a role in atrial reactive oxygen species balance and remodeling, which may contribute to atrial arrhythmogenesis.

Cite This Study

Hwang et al. (2015) studied this question.

synapsesocial.com/papers/6a8cfeeaa3cab2023a71b732https://doi.org/10.14814/phy2.12559
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