Why the study?
Does oral contraceptive therapy cause intravascular thrombosis in healthy women?
Does oral contraceptive therapy cause intravascular thrombosis in healthy women?
This case series highlights the potential risk of severe intravascular thrombosis, including both pulmonary embolism and arterial thrombosis, associated with oral contraceptive use in healthy women.
Alerts clinicians to possible fatal thrombosis with oral contraceptives; case series leaves causal link open for prospective studies.
3 healthy women aged 35 22 and 28 years developed intravascular thrombosis while receiving oral contraceptive therapy (Case 1 took Anovlar for 1 years Case 2 took Conovid for 18 months and Case 3 took Enovid for 1 month). Cases 2 and 3 had chest lesions and were treated as pulmonary embolic disease. Case 1 was fatal and directs attention to the possibility that arterial thrombosis (in this case carotid) may also exist in addition to the more thrombophlebitis of the legs and pulmonary embolism.
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Nevin et al. (1965) studied this question.
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