Epitaxy of a Structurally Related Compound on the (100) Faces of Flufenamic Acid Form I and III Single Crystals

Epitaxy is a form of two-dimensional heterogeneous nucleation in which the substrate induces a particular crystal phase of another compound. Here we describe the epitaxial sublimation behavior of a structurally related compound, mefenamic acid on the (100) faces of flufenamic acid form I and III single crystals. Raman microscopy, powder X-ray diffraction, and morphology analysis demonstrated that the epitaxial crystals of mefenamic acid were the most stable form. The mefenamic acid crystals showed a specific orientation with respect to the substrate, which was explained by lattice matching of the epitaxial crystal with respect to the host crystal.