associated with aging. Thus, the question arises whether or not a exists between the well known prostatic androgen and accumulation and aging. To address this question, we measured 5a-dihydrotestosterone (DHT), testosterone, estradiol, and estrone epithelium and stroma of six normal (NPR) and 19 BPH and the values with the age of the donors (26-87 yr). The mean level in NPR epithelium was significantly higher than in NPR , and also significantly higher than in epithelium and stroma of . The epithelial DHT level of NPR and BPH decreased with age, correlation being statistically significant. The stromal DHT level NPR and BPH showed no correlation with age. Concerning testosterone, rather low values were found which showed no correlation age. The mean levels of estradiol and estrone were higher in BPH stroma as compared to BPH epithelium well as to NPR epithelium and stroma. In NPR, the mean levels of and estrone were significantly higher in epithelium than . In NPR and BPH, the stromal estradiol and estrone levels significantly with age. In epithelium such a correlation between estrogen levels and age was not found. Our results indicate the prostatic accumulation of DHT, estradiol, and estrone is in intimately correlated with aging, leading with increasing age to a increase of the estrogen/androgen ratio particularly in stroma BPH.
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Michael Krieg (1993) studied this question.