Wirkstoffe aus Pilzen, I. Isolierung, Synthese und biologische Wirkung von Coniothyriomycin sowie Synthese und Biotestung analoger offenkettiger Imide

Biologically Active Metabolites of Fungi, I. — Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analoguos Open‐Chain Imides The mixed open‐chain imide N‐(3‐chloro‐4‐hydroxyphenyl‐acetyl)fumarate (1), named coniothyriomycin, was isolated as metabolite of the fungus Coniothyrium. The natural product 1 and the analoguos imides 13–15 and 22–24 have been synthesized by base‐catalyzed condensation of the imidates 12a–f with acid chlorides 6a–c or the mixed anhydride 21. The compounds 1 and 13–15 were shown to posess remarkable fungicidal and herbicidal activities in short‐termed tests.