The features of apoptotic dose responses typically have been evaluated over a broad dose-response continuum to differentiate apoptotic and necrotic responses. The present article specifically addresses the dose-response relationship for apoptosis in detail. It was determined that a number of well-documented cases exist in which the dose-response relationship for apoptosis is biphasic. The underlying mechanisms and biomedical implications of this biphasic dose-response phenomenon are discussed.
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Edward J. Calabrese (2001) studied this question.
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