Hyperthermic Cancer Therapy Combined with Inhibitors Targeted Against Heat-induced Signaling Factors

In this review, we summarize the molecular mechanisms of chemical inhibitors and small interference RNAs (siRNAs) specifically targeted against signaling factors involving in heat-induced signal transduction pathways for anti-apoptosis/cellular proliferation and DNA repair. Since there are still few reports of the chemical inhibitors and siRNAs with respect to sensitization to heat, the effective chemical inhibitors and siRNAs which block the signal transduction pathways are required from an aspect of fundamental research. We expect the attractive sensitizers described here to contribute to high curative efficiency in hyperthermic cancer therapy.