Evaluation of CA-125 and other biochemical parameters in premenopausal and postmenopausal women with ovarian cancer: a hospital based study from Western Nepal

To assess the status of carbohydrate antigen 125 (CA-125) and other biochemical parameters in premenopausal and postmenopausal ovarian cancer patients. Total 64 cases, out of which 43 premenopausal and 21 postmenopausal ovarian cancer patients were included in the study. Twenty-five premenopausal and twenty postmenopausal age-matched healthy control subjects were selected. The variables collected were age, CA-125, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), blood sugar, adenosine deaminase (ADA) and vitamin E. The data was analyzed by using Statistical Package for the Social Sciences for Windows Version 16.0. In premenopausal women, significant differences were noted for CA-125 (P<0.005), triglycerides (P<0.009), HDL-C (P<0.001), blood sugar (P<0.001) and ADA (P<0.002) and in postmenopausal women, significant differences were noted for CA-125 (P<0.001), triglycerides (P<0.001), blood sugar (P<0.001), ADA (P<0.005) and vitamin E (P<0.002) when compared with controls. Insignificant results were found for total cholesterol (P=0.100), LDL-C (P=0.104) and vitamin E (P=0.142) in premenopausal women and total cholesterol (P=0.670), HDL-C (P=0.472), LDL-C (P=0.272) in postmenopausal women when compared with healthy control subjects. Evaluation of CA-125 and other biochemical parameters may be important for control of ovarian cancer and to improved survival rate.