Hyaluronate-Proteoglycan Complex: Evidence for Separate Biosynthesis Mechanisms of the Macromolecules

In cartilage cells biosynthesis of hyaluronate and chondroitin-4-,-6-sulfate from proteoglycan takes place via two different distinct precursor pools; the synthesis of hyaluronate appears to require the unaffected formation of nucleotides and nucleic acids, whereas that of proteoglycan is very sensitive to the modulation of protein biosynthesis.