The interaction between the anionic polysaccharide sodium hyaluronate (NaHy) and the positively charged surfactant tetradecyltrimethylammonium bromide (TTAB) in water leads to phase separation if an insufficient amount of salt (NaCl in this study) is added. With increasing TTAB concentration a pronounced interaction remains even under single-phase conditions. This is experimentally supported by a lowered relative viscosity, a decreased electrophoretic mobility as determined by high performance capillary electrophoresis (HPCE) approaching zero mobility at infinite TTAB concentrations, and changes in hydrodynamic size as well as an increased relative scattered intensity as determined by quasi elastic light scattering (QELS). The extent of this interaction is controlled mainly by the ionic strength of the solution and by the concentration of surfactant. The data obtained are reasonably explained by the model developed in interaction studies of a positively charged polymer with a negatively charged surfactant.
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Herslöf-Björling et al. (1996) studied this question.
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