Intrarenal Arterial Network Renin Content and Inhibition by EMD 58265

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Population

Tissues from six rabbits, specifically renal cortical samples and intrarenal arterial network with and…

Comparison

EMD 58265 at 1 x 10 mol/L and 5 x 10 mol/L vs Uninhibited tissue samples

Design

Preclinical

Authors

Discussion

Renin in intrarenal arteries may enable local angiotensin generation; leaves open its role in human hypertension and targeted inhibition.

Population

Tissues from six rabbits, specifically renal cortical samples (RC) and intrarenal arterial network (IAN) with and without glomeruli.

Intervention

EMD 58265 (specific renin inhibitor) at 1 x 10(-8) mol/L and 5 x 10(-8) mol/L

Comparator

Uninhibited tissue samples

Outcome

Renin content (expressed as nanograms of angiotensin I generated per hour per milligram of tissue)surrogate

Small arteries comprising the intrarenal arterial network contain renin, and its enzymatic activity is specifically inhibited by EMD 58265.

P BIRT (1995) studied this question.

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