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Since 1970s HPLC received growing attention among catecholamine (CA) assay methods. Earlier methods such as colorimetric (1) or fluorimetric (2) nowadays seem obsolete. Radiotracer methods are usually effective for the determination of norepi-nephrine (NE) and epinephrine (Epi) in human plasma, although the high cost per sample, the poor sensitivity regarding plasma dopamine (DA), the involvement of radiolabelled compounds and the te-
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Musso et al. (1990) studied this question.
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