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Allergic contact dermatitis is the most common cause of peri-orbital eczema and may be caused by ophthalmic medicaments. A large series of selected patients affected by eyelid dermatitis believed to be caused by ophthalmic drugs have been submitted to patch tests. Negative reactions to patch test with ophtalmic products are often observed despite the history of the patients.
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Corazza et al. (2004) studied this question.
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