In summary, it is apparent that the renal sodium retention in patients with advanced liver disease constitutes a complex pathophysiologic constellation with numerous and diverse causes. In this article, I have brieftly reviewed the clinical features and pathophysiology of renal sodium retention in liver disease. Based on these pathophysiologic considerations, I have proposed an approach to the therapy of this renal derangement.
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Murray Epstein (1983) studied this question.
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