Synthesis of Functionalized Cyclic Molecules by Palladium-Catalyzed Cyclization of Propargylic Esters with Bis-nucleophiles

It is known that propargylic esters react with palladium complex leading to -propargylpalladium complexes, which further cause various transformations in the presence of soft nucleophiles to produce the corresponding products.Among them, palladium-catalyzed cyclization of propargylic esters with bis-nucleophiles is one of the useful methodologies for the construction of functionalized cyclic molecules in one step.Since the pioneering work reported by Tsuji in 1985, a considerable number of reactions have been reported by the use of various bis-nucleophiles.In this review, a comprehensive overview of the studies on palladium-catalyzed reactions of propargylic esters with bis-nucleophiles is described, in which various functionalized cyclic molecules can be synthesized in a regio-and stereoselective manner.