Cortisone-Induced Metastases of Adenocarcinoma in Mice.

Local growth of transplantable adenocarcinoma K7 in C3H mice was arrested when cortisone was given. Metastases of transplanted adenocarcinoma were never observed in untreated animals. However, metastases appeared at about 5 to 6 weeks after transplantation in animals treated with cortisone. The longer the animals survived, the greater was the incidence of cortisone-induced metastases. The cortisone-induced metastases also were transplantable and produced local growth. But local growth due to transplantation of metastases did not produce metastases unless cortisone was given to the new host.