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January 1, 1986Infection and ImmunityOpen Access

Neutralization of lymphokine-mediated antirickettsial activity of fibroblasts and macrophages with monoclonal antibody specific for murine interferon gamma

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Population

L929 fibroblasts and macrophages infected with Rickettsia prowazekii or Rickettsia conorii

Design

Preclinical

Authors

TJThomas R. JerrellsTulane UniversityJTJ TurcoValdosta State UniversityHWH H WinklerUppsala University

Discussion

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Implication

IFN-γ mediates antirickettsial activity in fibroblasts and macrophages; leaves open any therapeutic role in rickettsial infections.

Structured PICO

P
Population
L929 fibroblasts and macrophages infected with Rickettsia prowazekii or Rickettsia conorii
I
Intervention
Monoclonal antibody specific for murine interferon-gamma (soluble or conjugated to Sepharose beads)
O
Outcome
Neutralization of lymphokine-mediated antirickettsial activity (inhibition of Rickettsia multiplication)

Monoclonal antibody specific for murine interferon-gamma neutralizes lymphokine-mediated antirickettsial activity in fibroblasts and macrophages.

Cite This Study

Jerrells et al. (1986) studied this question.

synapsesocial.com/papers/6a8d2298b91fff50a6314c7ahttps://doi.org/10.1128/iai.51.1.355-359.1986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of T-lymphocytes in production of antibody to antigens of Rickettsia tsutsugamushi and other Rickettsia species1983 · 30 citations
  2. 2Effect of mouse lymphokines and cloned mouse interferon-gamma on the interaction of Rickettsia prowazekii with mouse macrophage-like RAW264.7 cells1984 · 43 citations
  3. 3Immune responses to Rickettsia akari infection in congenitally athymic nude mice1980 · 35 citations
  4. 4Interferonlike factors from antigen- and mitogen-stimulated human leukocytes with antirickettsial and cytolytic actions on Rickettsia prowazekii. Infected human endothelial cells, fibroblasts, and macrophages.1983 · 71 citations
  5. 5Enhanced production of murine interferon gamma by T cells generated in response to bacterial infection.1982 · 92 citations