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Abstract The hydrophobicity constants (μ) of different aromatic substituents have been factored into three major components, a volume factor (MW, or Vw), an electronic factor as represented by dipole moment (μ), and H‐bonding factor. The following general equation has been shown to be applicable to a wide range of nonpolar to polar substituents, with only a few notable outliers: π = a · MW (or Vw) ‐ b · HB ‐ c · μ + d. The usefulness and the limitations of such a general correlation are discussed.
Yang et al. (1986) studied this question.
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